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Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are bound

26 Jan 2023

Abstract excerpt

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) circumvent...

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PMID: 36778879
DOI: 10.3389/fmicb.2023.1069789

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