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A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals

8 Nov 2023

Abstract excerpt

Urinary tract infection is among the most common infections worldwide, typically studied in animals and cell lines with limited uropathogenic strains. Here, we assessed diverse bacterial species in a human urothelial microtissue model exhibiting full stratification, differentiation, innate epithelial responses, and urine tolerance. Several uropathogens invaded intracellularly, but also commensal Escherichia coli...

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PMID: 37939183
DOI: 10.1126/sciadv.adi9834

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