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Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis

20 May 2022

Abstract excerpt

Abstract Interstitial cystitis (IC) is a severely debilitating and chronic disorder with unclear etiology and pathophysiology, which makes the diagnosis difficult and treatment challenging. To investigate the role of immunity in IC bladders, we sequenced 135,091 CD45+ immune cells from 15 female patients with IC and 9 controls with stress urinary incontinence using single-cell RNA sequencing (scRNA-seq). 22...

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PMID: 35589692
DOI: 10.1038/s41392-022-00962-8

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