Article

JunB-HBZ nuclear translocation by TGF-β is a key driver in HTLV-1–mediated leukemogenesis

2024-10-07

Abstract excerpt

The HTLV-1 bZIP factor ( HBZ ) gene, which is the only viral gene conserved and consistently expressed in all adult T-cell leukemia-lymphoma (ATL) cases, is critical for ATL oncogenesis. Although HBZ protein is found in both the nucleus and the cytoplasm, the dynamics of HBZ protein localization and its contribution to oncogenesis have not been fully elucidated. In this study, we analyzed the subcellular express...

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Literature Corpus work: a1b1c546-e639-5445-9466-4735225663cf
DOI: 10.1101/2024.10.06.616923

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