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G-PGS: GPU-enabled whole-catalog PGS outperforms disease-specific PGS in complex disease profiling

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>Polygenic scores (PGS) quantify genome-wide genetic risks for multigenic diseases, yet clinical implementation is constrained by computational cost and the prevailing single-disease paradigm. Here we introduce G-PGS, a GPU-accelerated pipeline that scores an individual genome against the entire PGS Catalog (5,232 scores) in 78 minutes, achieving a 104-fold speedup with near-perfect conc...

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Literature Corpus work: a1a66c2b-dc6c-5738-9f97-5e7ea1e3a768
DOI: 10.21203/rs.3.rs-9510590/v1

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