Article

Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

2023-05-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> PTEN loss-of-function/PI3K pathway hyperactivation occurs in ∼50% of metastatic, castrate-resistant prostate cancer patients, resulting in poor therapeutic outcomes and resistance to immune checkpoint inhibitors across multiple malignancies. Our prior studies in prostate-specific PTEN/p53-deleted genetically engineered mice (Pb-Cre;PTEN fl/fl Trp53 fl/fl GEM) with aggressive-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a178ef6b-8ce5-54c4-9403-b424ad59a7c2
DOI: 10.1101/2023.05.23.540590

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosisDOI 10.1101/2023.05.23.540590Read

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancerSemantic proximity Read

Overcome Prostate Cancer Resistance to Immune Checkpoint Therapy with Ketogenic Diet-Induced Epigenetic ReprogrammingSemantic proximity Read

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancerSemantic proximity Read

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by sequential intermittent anti-PI3Kα/β/δ and anti-PD-1 treatmentSemantic proximity Read

Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer.Semantic proximity Read

Mutant p53 epigenetically rewires CXCL10 to promote CD8⁺ T-cell infiltration and enhance the anti-PD-1 response in advanced prostate cancer.Semantic proximity Read

RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of <i>Pten</i> -Mutant MetastasisSemantic proximity Read

Targeting the TLK1-Nek1-Mediated Activation of YAP1 Attenuates PD-L1 and Anti-Inflammation Set for Prostate Cancer ImmunoevasionSemantic proximity Read

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulatorSemantic proximity Read

Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imagingSemantic proximity Read

Targeting the TLK1-Nek1-Mediated Activation of YAP1 Attenuates PD-L1 and Inflammation Set for Prostate Cancer ImmunoevasionSemantic proximity Read

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancerSemantic proximity Read