Article
Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2.
Developmental biology - 1 Dec 1999
Maytin E V, Lin J C, Krishnamurthy R, Batchvarova N, Ron D, Mitchell P J, Habener J F
Abstract excerpt
The epidermis forms a vital barrier composed of stratified keratinocytes and their differentiated products. One of these products, keratin K10, is critical to epidermal integrity, because mutations in k10 lead to abnormal blistering. For the normal expression of k10, differentiation-associated transcription factors C/EBPalpha, C/EBPbeta, and AP-2 are well positioned to play an important role. Here, regulation of...
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