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Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion

20 Aug 2015

Abstract excerpt

Bacterial Sec7-domain-containing proteins (RalF) are known only from species of Legionella and Rickettsia, which have facultative and obligate intracellular lifestyles, respectively. L. pneumophila RalF, a type IV secretion system (T4SS) effector, is a guanine nucleotide exchange factor (GEF) of ADP-ribosylation factors (Arfs), activating and recruiting host Arf1 to the Legionella-containing vacuole. In contrast,...

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PMID: 26291822
DOI: 10.1371/journal.ppat.1005115

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