Article

Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of Class B1 GPCRs, CGRP and PTH1 receptors, in native-like nanodiscs

2026-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Class B1 G-protein-coupled receptors (GPCRs), such as the calcitonin gene-related peptide (CGRP) receptor and parathyroid hormone 1 (PTH1) receptor, require native lipid interactions to maintain signalling-competent conformations. However, conventional detergents disrupt these environments. Amphipathic copolymers offer a detergent-free alternative, yet the field still lacks a clear understanding...

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Literature Corpus work: a14d9c92-e697-5026-9592-2181eb6d6e67
DOI: 10.64898/2026.05.13.724797

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