Article

Cardiac Calsequestrin is a Physiological Dimer that Polymerizes through a Ca²⁺-Triggered Cooperative Switch

2026-04-07

Abstract excerpt

Cardiac Calsequestrin (CASQ2) polymerizes within the junctional sarcoplasmic reticulum to buffer Ca²⁺ and regulate ryanodine receptor 2 (RyR2) gating, yet the molecular mechanism governing this process remains poorly understood. Using an integrated set of complementary approaches spanning single-particle biophysics, bulk solution measurements, and polymer chemistry, we demonstrate that CASQ2 is an intrinsic dimer...

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Literature Corpus work: 58ce33ef-b6f0-5606-861c-a3d42faedf66
DOI: 10.64898/2026.04.04.716468

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