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Article

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

PLoS medicine - 4 Mar 2008

Heazlewood Chad K, Cook Matthew C, Eri Rajaraman, Price Gareth R, Tauro Sharyn B, Taupin Douglas, Thornton David J, Png Chin Wen, Crockford Tanya L, Cornall Richard J, Adams Rachel, Kato Masato, Nelms Keats A, Hong Nancy A, Florin Timothy H J, Goodnow Christopher C, McGuckin Michael A

Abstract excerpt

BACKGROUND: MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18318598
DOI: 10.1371/journal.pmed.0050054
PMCID: PMC2270292

Genes

MUC2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18318598-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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