Article

Allosteric modulation of the Lon protease by effector binding and local charges

2024-09-06

Abstract excerpt

The ATPase Associated with diverse cellular Activities (AAA+) family of proteases play crucial roles in cellular proteolysis and stress responses. Like other AAA+ proteases, the Lon protease is known to be allosterically regulated by nucleotide and substrate binding. Although it was originally classified as a DNA binding protein, the impact of DNA binding on Lon activity is unclear. In this study, we characterize...

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Literature Corpus work: a149eab1-ab41-5cca-9f5f-18cc79c007c7
DOI: 10.1101/2024.09.06.611642

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