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Article

Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009

Gur Eyal, Sauer Robert T

Abstract excerpt

AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally viewed as a passive reaction. By contrast, for the AAA+ Lon protease, we show that degron tags are also regulatory elements that determine protease activity levels. Indeed, different tags fused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19841274
DOI: 10.1073/pnas.0910392106
PMCID: PMC2774003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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