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Interplay Between Fibroblast Growth Factor-19, Beta-Klotho and Receptors Impact Cardiovascular Risk in Chronic Kidney Disease

2025-12-19

Abstract excerpt

Chronic kidney disease (CKD) markedly increases the risk of cardiovascular events (CVE), yet conventional biomarkers often fail to capture this excess risk. We evaluated whether circulating levels and genetic variability within the FGF19/β-Klotho/FGFR axis contribute to CV risk stratification in CKD. In 579 CKD patients, plasma FGF19 and β-Klotho con-centrations were quantified, and 64 genetic variants across FGF1...

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Literature Corpus work
a140445f-40f8-52da-b85a-ef63ea8754ec
DOI
10.20944/preprints202512.1750.v1
Open publication

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