Article

VarDCL: A Multimodal PLM-Enhanced Framework for Missense Variant Effect Prediction via Self-distilled Contrastive Learning

2026-03-17

Abstract excerpt

Missense variants are a common type of genetic mutation that can alter the structure and function of proteins, thereby affecting the normal physiological processes of organisms. Accurately distinguishing damaging missense variants from benign ones is of great significance for clinical genetic diagnosis, treatment strategy development, and protein engineering. Here, we propose the VarDCL method, which ingeniously i...

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Literature Corpus work: a12ca458-e7e7-5ce7-9f63-31e1a72c49be
DOI: 10.64898/2026.03.13.711612

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