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Article

TransPPMP: predicting pathogenicity of frameshift and non-sense mutations by a Transformer based on protein features.

Bioinformatics (Oxford, England) - 13 May 2022

Nie Liangpeng, Quan Lijun, Wu Tingfang, He Ruji, Lyu Qiang

Abstract excerpt

MOTIVATION: Protein structure can be severely disrupted by frameshift and non-sense mutations at specific positions in the protein sequence. Frameshift and non-sense mutation cases can also be found in healthy individuals. A method to distinguish neutral and potentially disease-associated frameshift and non-sense mutations is of practical and fundamental importance. It would allow researchers to rapidly screen...

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PMID: 35561183
DOI: 10.1093/bioinformatics/btac188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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