Article

Memo-Patho: Bridging Local-Global Transmembrane Protein Contexts with Contrastive Pretraining for Alignment-Free Pathogenicity Prediction

2025-05-23

Abstract excerpt

Understanding the pathogenic impact of protein mutations remains a fundamental challenge in genomic medicine, particularly for transmembrane proteins (TMPs), a functionally critical yet structurally under-annotated class that includes numerous drug targets. Current variant effect predictors often fall short in this domain due to computational burdens, reliance on multiple sequence alignments (MSAs), and limited ab...

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Literature Corpus work: d086702d-0deb-5370-a40e-7b6cf83956c4
DOI: 10.1101/2025.05.18.654712

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