DisoPatho: A Cross-View Feature-Adaptive Interaction Encoding Framework for Predicting Disease-Associated Variants in Intrinsically Disordered Regions.

Abstract excerpt

Accurate prediction of variants within intrinsically disordered regions (IDRs) is crucial for advancing disease diagnosis and biomedical interpretation. However, the intrinsic lack of stable structural conformations and the high sequence variability of IDRs make it challenging for existing predictors to achieve robust performance in these regions. Here, we introduce DisoPatho, a deep learning framework...

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