Article

EvoStructCLIP: A Mutation-Centered Multimodal Embedding Model for CAGI7 Variant Effect Prediction

2026-03-04

Abstract excerpt

We present EvoStructCLIP, a mutation-centered multimodal embedding model that integrates local 3D structural windows and evolutionary constraints to predict missense variant effects. EvoStructCLIP combines two encoders: a structure voxel encoder derived from AlphaFold residue neighborhoods and an MSA-based evolutionary encoder. It aligns the modalities through CLIP-style contrastive learning, with FuseMix regulari...

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Literature Corpus work: 93855412-eddd-5e6c-8130-092e258ce573
DOI: 10.64898/2026.03.02.707336

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