Article

A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures

2020-04-01

Abstract excerpt

<title>Abstract</title> <p>Background Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) and, in these cases, ERα targeting is the main therapeutic strategy. However, the biological determinants of ERα heterogeneity and the mechanisms underlying therapeutic...

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Literature Corpus work: a12611a9-6981-5a38-8fca-59a7fbb3eef9
DOI: 10.21203/rs.3.rs-20405/v1

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