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A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures

17 Aug 2020

Abstract excerpt

BACKGROUND: Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) and, in these cases, ERα targeting is the main therapeutic strategy. However, the biological determinants of ERα heterogeneity and the mechanisms underlying therapeutic resistance are still...

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PMID: 32807212
DOI: 10.1186/s13046-020-01653-4

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