Ethanol drinking sex-dependently alters cortical IL-1β synaptic signaling and cognitive behavior in mice

Abstract excerpt

Individuals with alcohol use disorder (AUD) struggle with inhibitory control, decision making, and emotional processing. These cognitive symptoms reduce treatment adherence, worsen clinical outcomes, and promote relapse. Neuroimmune activation is a key factor in the pathophysiology of AUD, and targeting this modulatory system is less likely to produce unwanted side effects compared to directly targeting neurotrans...

Topics

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• Alcoholism
• Behavior, Addictive
• Disease Models, Animal
• Gene Expression
• Microarray Analysis
• NF-kappa B
• Prefrontal Cortex
• Sex Characteristics

Identifiers and source

Literature Corpus work

a114a4b6-43e7-5e39-805b-83d101f38e9a

DOI

10.1101/2024.10.08.617276