Article

RhoA effectors LOK/SLK activate ERM proteins to locally inhibit RhoA and define apical morphology

2020-07-02

Abstract excerpt

Activated Ezrin-Radixin-Moesin (ERM) proteins link the plasma membrane to the actin cytoskeleton to generate apical structures, including microvilli. Among many kinases implicated in ERM activation are the homologs LOK and SLK. CRISPR/Cas9 was used to knockout all ERM proteins or LOK/SLK in human cells. LOK/SLK knockout eliminates all ERM activating phosphorylation. The apical domain of cells lacking LOK/SLK or ER...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a11128d7-0c6c-5d7c-9a36-5039aea2f734
DOI: 10.1101/2020.07.02.185298

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RhoA effectors LOK/SLK activate ERM proteins to locally inhibit RhoA and define apical morphologyDOI 10.1101/2020.07.02.185298Read

Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity.Semantic proximity Read

A glimpse of the ERM proteinsSemantic proximity Read

Pathophysiological Roles of Actin-Binding Scaffold Protein, EzrinSemantic proximity Read

ERM proteins in epithelial cell organization and functionsSemantic proximity Read

ERM proteins in cancer progressionSemantic proximity Read

Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine.Semantic proximity Read

Rho Kinases in Embryonic Development and Stem Cell ResearchSemantic proximity Read

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cellsSemantic proximity Read

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.Semantic proximity Read

Ezrin Phosphorylation at T567 Modulates Cell Migration, Mechanical Properties, and Cytoskeletal Organization.Semantic proximity Read

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of SignalingSemantic proximity Read

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.Semantic proximity Read