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Article

Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity.

Nature - 2 Jan 2003

Speck Olga, Hughes Sarah C, Noren Nicole K, Kulikauskas Rima M, Fehon Richard G

Abstract excerpt

Two prominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton, depend on the existence of precisely localized protein complexes associated with the apical plasma membrane, and on a separate machinery that regulates the spatial order of actin assembly. ERM (ezrin, radixin, moesin) proteins have been proposed to link transmembrane proteins to the actin cytoskeleton in...

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Identifiers

PMID: 12511959
DOI: 10.1038/nature01295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity.PMID 12511959Read ↗

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RhoA effectors LOK/SLK activate ERM proteins to locally inhibit RhoA and define apical morphologySemantic proximity Read ↗

Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout.Semantic proximity Read ↗

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cellsSemantic proximity Read ↗

Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells.Semantic proximity Read ↗

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of SignalingSemantic proximity Read ↗

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A ReviewSemantic proximity Read ↗

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transductionSemantic proximity Read ↗

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