Article

One substrate-many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

2023-09-18

Abstract excerpt

<title>Abstract</title> <p>The increasing availability of experimental and computational protein structures entices their use for function prediction. We developed a structure-based automated procedure to identify proteins involved in metabolic reactions by evaluating substrate conformations docked to a library of enzyme active sites. By screening AlphaFold-modeled vitamin B6-dependent enzymes, we found that a me...

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Literature Corpus work: a0faf9b3-2840-508a-82d2-29b85566189c
DOI: 10.21203/rs.3.rs-3295520/v1

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One substrate-many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouseDOI 10.21203/rs.3.rs-3295520/v1Read

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