Article

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

2022-05-20

Abstract excerpt

<h4>ABSTRACT</h4> In humans, a single enzyme 2-aminoadipic semialdehyde synthase (AASS) catalyzes the initial two critical reactions in the lysine degradation pathway. This enzyme evolved to be a bifunctional enzyme with both lysine 2-oxoglutarate reductase (LOR) and saccharopine dehydrogenase domains (SDH). Moreover, AASS is a unique drug target for metabolic genetic diseases such as glutaric aciduria type 1 tha...

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Literature Corpus work: 8e6bed8e-93e9-511e-a847-606c1d488333
DOI: 10.1101/2022.05.20.492856

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