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Article

Apollo contributes to G overhang maintenance and protects leading-end telomeres.

Molecular cell - 27 Aug 2010

Wu Peng, van Overbeek Megan, Rooney Sean, de Lange Titia

Abstract excerpt

Mammalian telomeres contain a single-stranded 3' overhang that is thought to mediate telomere protection. Here we identify the TRF2-interacting factor Apollo as a nuclease that contributes to the generation/maintenance of this overhang. The function of mouse Apollo was determined using Cre-mediated gene deletion, complementation with Apollo mutants, and the TRF2-F120A mutant that cannot bind Apollo. Cells lacking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20619712
DOI: 10.1016/j.molcel.2010.06.031
PMCID: PMC2929323

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Apollo contributes to G overhang maintenance and protects leading-end telomeres.PMID 20619712Read ↗

Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal–Hreidarsson syndromeSemantic proximity Read ↗

DCLRE1B/hSNM1B (Apollo) is not acutely required for human pluripotent stem cell survivalSemantic proximity Read ↗

Apollo, an Artemis-Related Nuclease, Interacts with TRF2 and Protects Human Telomeres in S PhaseSemantic proximity Read ↗

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strandsSemantic proximity Read ↗

TRF2 Protects Human Telomeres from End-to-End FusionsSemantic proximity Read ↗

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative DamageSemantic proximity Read ↗

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusionsSemantic proximity Read ↗

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