Article

An <i>in vivo</i> avian model of human melanoma to perform rapid and robust preclinical studies

2022-10-13

Abstract excerpt

Metastatic melanoma patients carrying a BRAF V600 mutation can be treated with BRAF inhibitors (BRAFi), in combination with MEK inhibitors (MEKi), but innate and acquired resistance invariably occurs. Resistance can involve transcriptional- and epigenetic-based phenotypic adaptations, as yet unpredictable. Predicting patient response to targeted therapies is crucial to guide clinical decision. We describe here th...

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Literature Corpus work: a0e2cef4-8896-5de0-b9fb-fee33947c508
DOI: 10.1101/2022.10.12.511927

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