Article
An in vivo avian model of human melanoma to perform rapid and robust preclinical studies.
EMBO molecular medicine - 8 Mar 2023
Jarrosson Loraine, Dalle Stéphane, Costechareyre Clélia, Tang Yaqi, Grimont Maxime, Plaschka Maud, Lacourrège Marjorie, Teinturier Romain, Le Bouar Myrtille, Maucort-Boulch Delphine, Eberhardt Anaïs, Castellani Valérie, Caramel Julie, Delloye-Bourgeois Céline
Abstract excerpt
Metastatic melanoma patients carrying a BRAFV600 mutation can be treated with a combination of BRAF and MEK inhibitors (BRAFi/MEKi), but innate and acquired resistance invariably occurs. Predicting patient response to targeted therapies is crucial to guide clinical decision. We describe here the development of a highly efficient patient-derived xenograft model adapted to patient melanoma biopsies, using the avian...
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