Article

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

2025-03-20

Abstract excerpt

Proteomic profiling of Alzheimer’s disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with Aβ since the early disease stage, but their roles in disease progression are not fully understood. Here we present that MDK attenuates Aβ assembly and influences amyloid formation in the 5xFAD amyloidosis mouse model. MDK protein mitigates fi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0500c7f8-4324-5050-9a31-8c0fd0f61964
DOI: 10.1101/2025.03.20.644383

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque FormationDOI 10.1101/2025.03.20.644383Read

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque FormationSemantic proximity Read

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s diseaseSemantic proximity Read

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicitySemantic proximity Read

Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer’s diseaseSemantic proximity Read

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s diseaseSemantic proximity Read

Quantitative proteomic analysis of the hippocampus in the 5XFAD mouse model at early stages of Alzheimer's disease pathology.Semantic proximity Read

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged miceSemantic proximity Read

The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.Semantic proximity Read

The many connections of UFMylation with Alzheimer’s disease: a comprehensive reviewSemantic proximity Read

Genetic knockdown of Klk8 has sex‐specific multi‐targeted therapeutic effects on Alzheimer’s pathology in miceSemantic proximity Read

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.Semantic proximity Read

Structure of Crenezumab Complex with Aβ Shows Loss of β-HairpinSemantic proximity Read