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Article

Astrocyte fatty acid metabolism as a driver of risk for major depressive disorder.

Nature communications - 8 Apr 2026

Fitzgerald Eamon, O'Toole Nicholas, Pokhvisneva Irina, Nestler Eric J, Turecki Gustavo, Nagy Corina, Meaney Michael J

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified genetic loci associated with major depressive disorder (MDD), yet the complex gene networks underpinning this polygenic risk remain largely uncharacterised. Here, we elucidate the neurobiological mechanisms of MDD by analyzing co-expression networks of 94 risk genes in the human prefrontal cortex. By linking these networks to individual symptoms,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41951638
DOI: 10.1038/s41467-026-71542-5
PMCID: PMC13237068

Genes

FADS1
FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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