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Design of bacteriophage T4-based artificial viral vectors for human genome remodeling

30 May 2023

Abstract excerpt

Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications. Here, we describe an assembly-line approach to build AVVs by engineering the well-characterized structural components of bacteriophage T4. Starting with a 120 × 86 nm capsid shell that can accommodate 171-Kbp DNA and thousands of protein copies, various...

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PMID: 37253769
DOI: 10.1038/s41467-023-38364-1

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