Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma

20 Jun 2019

Abstract excerpt

MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood. We show that MYC rearrangements are present in 36.0% of newly diagnosed myeloma patients, as detected in the largest set of next generation sequencing data to date...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31221783
DOI: 10.3324/haematol.2019.217927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myelomaPMID 31221783Read ↗

Microhomology-mediated end joining drives complex rearrangements and over-expression of <i>MYC</i> and <i>PVT1</i> in multiple myelomaSemantic proximity Read ↗

Multiple myeloma immunoglobulin lambda translocations portend poor prognosisSemantic proximity Read ↗

Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patientsSemantic proximity Read ↗

Whole Exome Sequencing in Multiple Myeloma to Identify Somatic Single Nucleotide Variants and Key Translocations Involving Immunoglobulin Loci and MYC.Semantic proximity Read ↗

Revealing the Impact of Structural Variants in Multiple MyelomaSemantic proximity Read ↗

Structural variants shape the genomic landscape and clinical outcome of multiple myelomaSemantic proximity Read ↗

Revealing the impact of recurrent and rare structural variants in multiple myelomaSemantic proximity Read ↗

Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple MyelomaSemantic proximity Read ↗

Impact of rare structural variant events in newly diagnosed multiple myelomaSemantic proximity Read ↗

Evolution and structure of clinically relevant gene fusions in multiple myelomaSemantic proximity Read ↗

Characterization of MYC Rearrangements in Multiple Myeloma: an Optical Genome Mapping ApproachSemantic proximity Read ↗

Expressed fusion gene landscape and its impact in multiple myelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.