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METTL1-driven epitranscriptomic enhancement of TXNDC12 boosts c-Myc stability through USP5 in HNSCC

1 Aug 2025

Abstract excerpt

Abstract Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy worldwide. Advancing understanding of the molecular mechanisms driving tumor progression and resistance to therapy is essential for developing new strategies to improve patient outcomes in HNSCC. Here we demonstrate that elevated expression of thioredoxin domain-containing protein 12 (TXNDC12) in HNSCC is associated with adverse...

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PMID: 40750708
DOI: 10.1038/s12276-025-01512-2

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