Article

Synthesis of some sulfonamide derivatives coupled with salicylamide or anisamide scaffold as potent PD-L1 inhibitors and their anti-proliferation assay

2023-06-14

Abstract excerpt

<title>Abstract</title> <p>The present study explores the potential of the new sulfonamide derivatives coupled with salicylamide or anisamide scaffold as immune checkpoint PD-L1 inhibitors. Based on <italic>in silico</italic> virtual screening 32 derivatives were synthesized and tested in vitro as PD-L1 inhibitors using screening ELISA assay. Five compounds gave promised results with more than 50% inhibition. The...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fe09246-e7d9-5a2e-8015-895a90e3654f
DOI: 10.21203/rs.3.rs-3043237/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synthesis of some sulfonamide derivatives coupled with salicylamide or anisamide scaffold as potent PD-L1 inhibitors and their anti-proliferation assayDOI 10.21203/rs.3.rs-3043237/v1Read

Recent Development of Sulfonyl or Sulfonamide Hybrids as Potential Anticancer Agents: A Key ReviewSemantic proximity Read

Synthesis and evaluation of methoxyquinazoline sulfonamide derivatives as bifunctional molecular targeting tumor related inflammation and anti-EGFR triple-mutation.Semantic proximity Read

A STAT inhibitor patent review: progress since 2011Semantic proximity Read

<i>In silico</i> molecular target prediction unveils mebendazole as a potent MAPK14 inhibitorSemantic proximity Read

Design, synthesis and biological evaluation of hybrids of β-carboline and salicylic acid as potential anticancer and apoptosis inducing agentsSemantic proximity Read

Anthraquinone derivatives as an immune booster and their therapeutic option against COVID-19Semantic proximity Read

A luciferase-based assay identifies niclosamide derivatives antagonizing Mcl-1 through post-translational down-regulationSemantic proximity Read

Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 InhibitorSemantic proximity Read

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and OpportunitiesSemantic proximity Read

Discovery and Characterization of 2-Aminobenzimidazole Derivatives as Selective NOD1 InhibitorsSemantic proximity Read

Drug repurposing: halogenated salicylanilides inhibit USP8 catalytic activity and ACTH release by pituitary cellsSemantic proximity Read

GPCR Inhibition in Treating LymphomaSemantic proximity Read