Synthesis and evaluation of methoxyquinazoline sulfonamide derivatives as bifunctional molecular targeting tumor related inflammation and anti-EGFR triple-mutation.

Abstract excerpt

The development of novel anti-cancer compounds that overcome acquired resistance to third-generation EGFR inhibitors such as osimertinib is of great significance. This study designed and synthesized eighteen methoxyquinazoline sulfonamide derivatives, and evaluated their anti-tumor activity using three EGFR triple-mutant tumor cell lines. Among them, the optimal compound 9f exhibited IC₅₀ values of 33.3-95.3 nM...

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