Back to search

Article

A Single Point Mutation in GraS Drives Co-Evolution of Vancomycin Resistance and Virulence in <em>Staphylococcus aureus</em>

2026-05-12

Abstract excerpt

The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) threatens the efficacy of this last-line antibiotic. The GraSR two component system is frequently mutated in VISA strains. Here, we demonstrate that the GraS(T136I) point mutation, identified in the clinical VISA isolate XN108, is a key determinant of reduced vancomycin susceptibility. Introducing this mutation into the susceptible strain Newman...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9fc85139-ecfc-52dd-a7fc-1d1802755e94
DOI
10.20944/preprints202605.0829.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Single Point Mutation in GraS Drives Co-Evolution of Vancomycin Resistance and Virulence in <em>Staphylococcus aureus</em>DOI 10.20944/preprints202605.0829.v1
Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene <i>graS</i> That Leads to Intermediate Vancomycin Resistance in Clinical <i>Staphylococcus aureus</i>Semantic proximity
Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureusSemantic proximity
An induced mutation of ABC-transporter component VraF(K84E) contributes to vancomycin resistance and virulence in Staphylococcus aureus strain MW2.Semantic proximity
Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.Semantic proximity
The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA.Semantic proximity
Modulating activity of vancomycin and daptomycin on the expression of autolysis cell-wall turnover and membrane charge genes in hVISA and VISA strains.Semantic proximity
Prevalence of amino acid changes in the yvqF, vraSR, graSR, and tcaRAB genes from vancomycin intermediate resistant Staphylococcus aureusSemantic proximity
Site-Specific Mutation of the Sensor Kinase GraS in Staphylococcus aureus Alters the Adaptive Response to Distinct Cationic Antimicrobial PeptidesSemantic proximity
Investigation of the Staphylococcus aureus GraSR Regulon Reveals Novel Links to Virulence, Stress Response and Cell Wall Signal Transduction PathwaysSemantic proximity
Interaction of the GraRS Two-Component System with the VraFG ABC Transporter To Support Vancomycin-Intermediate Resistance in <i>Staphylococcus aureus</i>Semantic proximity
Differential daptomycin resistance development in Staphylococcus aureus strains with active and mutated gra regulatory systems.Semantic proximity
Acquired Vancomycin Resistance in Clinically Relevant PathogensSemantic proximity
Select a neighboring publication to make it the new centre.