Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene <i>graS</i> That Leads to Intermediate Vancomycin Resistance in Clinical <i>Staphylococcus aureus</i>

Abstract excerpt

Methicillin-resistant Staphylococcus aureus (MRSA), once restricted to hospitals, is spreading rapidly through the wider community. Resistance to vancomycin, the principal drug used to treat MRSA infections, has only recently emerged, is mainly low level, and characteristically appears during vancomycin therapy (vancomycin-intermediate S. aureus [VISA] and hetero-resistant VISA). This phenomenon suggests the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Resistance in Staphylococcus
• Share to Bacterial biofilms and quorum sensing
• Share to Bacterial Identification and Susceptibility Testing