Article
Modulating activity of vancomycin and daptomycin on the expression of autolysis cell-wall turnover and membrane charge genes in hVISA and VISA strains.
PloS one - 1 Jan 2012
Cafiso Viviana, Bertuccio Taschia, Spina Daniela, Purrello Simona, Campanile Floriana, Di Pietro Cinzia, Purrello Michele, Stefani Stefania
Abstract excerpt
Glycopeptides are still the gold standard to treat MRSA (Methicillin Resistant Staphylococcus aureus) infections, but their widespread use has led to vancomycin-reduced susceptibility [heterogeneous Vancomycin-Intermediate-Staphylococcus aureus (hVISA) and Vancomycin-Intermediate-Staphylococcus aureus (VISA)], in which different genetic loci (regulatory, autolytic, cell-wall turnover and cell-envelope positive...
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