MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging

Abstract excerpt

Iron is an essential metal cofactor for enzymes involved in many cellular functions such as energy generation and cell proliferation. However, excessive iron concentration leads to increased oxidative stress and toxicity. As such, iron homeostasis is strictly controlled by two RNA binding proteins known as Iron Regulatory Proteins (IRPs) that regulate at post-transcriptional level the expression of iron management...

Topics

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• Base Sequence
• Binding Sites
• Evolution, Molecular
• Gene Expression
• Iron Metabolism and Disorders
• Models, Biological
• Models, Molecular
• Mutation

Identifiers and source

Literature Corpus work

9f8c3e5a-4c39-5170-b20d-e69a2991e3f6

DOI

10.1101/046516