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Article

Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health

28 Nov 2017

Abstract excerpt

Abstract The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging heart. MiRNA-sequencing of 5 week (young), 12–21 week (adult) and 28–40 week (old) Nfu hearts revealed 23 up-regulated and 18 down-regulated miRNAs with...

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PMID: 29203887
DOI: 10.1038/s41598-017-16829-w

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