Article

Maternal transmission bias of inherited genetic variants in severe early-onset obesity

2022-09-01

Abstract excerpt

<title>Abstract</title> <p>Background: Obesity is highly influenced by genetics, with stronger genetic component in severe early-onset obesity (EOO). Heterozygous rare sequence variants (RSVs) affecting genes of the leptin-melanocortin pathway and hypothalamic function cause EOO, with variable expressivity and incomplete penetrance. We aimed to define whether and how parental inheritance could influence expressi...

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Literature Corpus work: 9f896a8f-4850-544f-b060-4a2af7758318
DOI: 10.21203/rs.3.rs-1991759/v1

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