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Article

Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease.

Cell - 24 Oct 2013

Folkmann Andrew W, Collier Scott E, Zhan Xiaoyan, Aditi, Ohi Melanie D, Wente Susan R

Abstract excerpt

The conserved multifunctional protein Gle1 regulates gene expression at multiple steps: nuclear mRNA export, translation initiation, and translation termination. A GLE1 mutation (FinMajor) is causally linked to human lethal congenital contracture syndrome-1 (LCCS1); however, the resulting perturbations on Gle1 molecular function were unknown. FinMajor results in a proline-phenylalanine-glutamine peptide insertion...

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Identifiers

PMID: 24243016
DOI: 10.1016/j.cell.2013.09.023
PMCID: PMC3855398

Genes

GLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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