Article

Proteomic profiling of Elp1-deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

2025-12-09

Abstract excerpt

<h4>Background</h4> Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain poorly defined. <h4>Results</h4> We performed quantitative prot...

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Literature Corpus work: 053748b7-c1bd-555b-b5e7-f17dc8c4cf75
DOI: 10.64898/2025.12.05.692685

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