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Article

Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting

15 May 2020

Abstract excerpt

mRNA processing is highly regulated during development through changes in RNA-binding protein (RBP) activities. CUG-BP, Elav-like family member 1 (CELF1, also called CUGBP1) is an RBP, the expression of which decreases in skeletal muscle soon after birth. CELF1 regulates multiple nuclear and cytoplasmic RNA processing events. In the nucleus, CELF1 regulates networks of postnatal alternative splicing (AS)...

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PMID: 32412585
DOI: 10.1093/hmg/ddaa095

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