Article

LFMD: detecting low-frequency mutations in high-depth genome sequencing data without molecular tags

2019-04-24

Abstract excerpt

As next-generation sequencing (NGS) and liquid biopsy become more prevalent in research and in the clinic, there is an increasing need for better methods to reduce cost and improve sensitivity and specificity of low-frequency mutation detection (where the Alternative Allele Frequency, or AAF, is less than 1%). Here we propose a likelihood-based approach, called Low-Frequency Mutation Detector (LFMD), which combine...

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Literature Corpus work: 9f52145b-6d4c-5e41-af0c-aa58142bdc64
DOI: 10.1101/617381

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