Article

ClonArch: Visualizing the Spatial Clonal Architecture of Tumors

2020-04-07

Abstract excerpt

<h4>Motivation</h4> Cancer is caused by the accumulation of somatic mutations that lead to the formation of distinct populations of cells, called clones. The resulting clonal architecture is the main cause of relapse and resistance to treatment. With decreasing costs in DNA sequencing technology, rich cancer genomics datasets with many spatial sequencing samples are becoming increasingly available, enabling the i...

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Literature Corpus work: 179a064c-faf1-500b-946b-f9563cda8712
DOI: 10.1101/2020.04.06.027912

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