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Article

Common pitfalls in drug target Mendelian randomization and how to avoid them.

BMC medicine - 15 Oct 2024

Gill Dipender, Dib Marie-Joe, Cronjé Héléne T, Karhunen Ville, Woolf Benjamin, Gagnon Eloi, Daghlas Iyas, Nyberg Michael, Drakeman Donald, Burgess Stephen

Abstract excerpt

BACKGROUND: Drug target Mendelian randomization describes the use of genetic variants as instrumental variables for studying the effects of pharmacological agents. The paradigm can be used to inform on all aspects of drug development and has become increasingly popular over the last decade, particularly given the time- and cost-efficiency with which it can be performed even before commencing clinical studies....

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PMID: 39407214
DOI: 10.1186/s12916-024-03700-9
PMCID: PMC11481744

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