Article
Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.
Molecular psychiatry - 1 Aug 2025
Reus Lianne M, Boltz Toni, Francia Marcelo, Bot Merel, Ramesh Naren, Koromina Maria, Pijnenburg Yolande A L, den Braber Anouk, van der Flier Wiesje M, Visser Pieter Jelle, van der Lee Sven J, Tijms Betty M, Teunissen Charlotte E, Loohuis Loes Olde, Ophoff Roel A
Abstract excerpt
Genomic studies of molecular traits have provided mechanistic insights into complex disease, though these lag behind for brain-related traits due to the inaccessibility of brain tissue. We leveraged cerebrospinal fluid (CSF) to study neurobiological mechanisms in vivo, measuring 5543 CSF metabolites, the largest panel in CSF to date, in 977 individuals of European ancestry. Individuals originated from two...
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