Article

Hematopoietic stem cell division is governed by distinct RUNX1 binding partners

2024-06-08

Abstract excerpt

A defined number of hematopoietic stem cell (HSC) clones are born during development and expand to form the pool of adult stem cells. An intricate balance between self-renewal and differentiation of these HSCs supports hematopoiesis for life. HSC fate is determined by complex transcription factor networks that drive cell-type specific gene programs. The transcription factor RUNX1 is required for definitive hematop...

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Literature Corpus work: 9eba434d-5a90-5322-b294-cc875465cf78
DOI: 10.1101/2024.06.07.596542

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